A recent study published in JAMA Psychiatry conducted a largest ever study that aimed to “systematically review the antidepressant and possible adverse effects of anti-inflammatory interventions.” The authors conducted a search for randomized placebo-controlled trials assessing the efficacy and adverse effects of pharmacologic anti-inflammatory treatment in adults with depression/depressive symptoms. The study evaluated 14 international studies with a total of 6,262 patients. The authors found that “anti-inflammatory treatment showed a beneficial effect on depressive symptoms without an increased risk for well-known adverse effects.”
