The Role of Immune System in the Effects of Early Interpersonal Adversity on Neural Predisposition to Chronic Pain

Title: The Role of Immune System in the Effects of Early Interpersonal Adversity on Neural Predisposition to Chronic Pain

Investigator: Alla Landa, PhD, Columbia University

Overview:  The proposed pilot study will involve processing with the Luminex technology the stored blood samples (which were already collected on the day of fMRI and challenged by an inflammatory stimulus Lipopolysaccharide-LPS) to obtain cytokine levels and analyzing the data in relation to already collected fMRI, EIA, pain sensitivity, and behavioral data (see preliminary Study II). Study Aims: Aim 1: To study the effects of EIA on immune makers.  Aim 2:To investigate immune markers of the neural modulation of pain by interpersonal rejection.  Aim 3: To investigate immune markers of the neural modulation of pain by interpersonal rejection.